Name: Dr. Jacob V. Maizel, Jr.

Date and Place of Birth: June 29, 1934; Harrisburg, Pennsylvania

Citizenship: United States

 Education:

June 1951-Graduated from New Bloomfield High School
June1955 -B.S. (Agricultural and Biological Chemistry), Pennsylvania State University, University Park, Pennsylvania
December1957-M.S. (Agricultural and Biological Chemistry/major, Chemistry/minor), Pennsylvania State University, University Park, Pennsylvania
June1959 -Ph.D. (Biochemistry), California Institute of Technology, Pasadena, California

 Brief Chronology of Employment:

 1959-1961-Senior Assistant Scientist, U.S.P.H.S., Laboratory of Cell Biology, National Institutes of Health, Bethesda, Maryland
1961-1967-Assistant Professor, Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York
1967-1972 -Associate Professor, Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York
1969-1970 -Visiting Scientist, Medical Research Council, Laboratory of Molecular Biology, Cambridge, England
1972-1974-Professor, Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York
1974-1984-Head, Section on Molecular Structure, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
1984-Date-Chief, NIH, NCI, DBS, Laboratory of Experimental and Computational Biology

Societies:
 
 

NCI representative to Communication and Information Technology Committee (CIT)

Member of the Advanced Software Technology and Algorithm working groups of HECCWG

Member of the IRM Strategic Planning Group

Member of the Advisory Panel to the Army High Performance Computing Research Center at the University of Minnesota (formerly)

Member of the Advisory Board for the Biomedical grant to the NSF Pittsburgh Supercomputing Center(formerly)

Member of the Frederick Cancer Research and Development Center's Director's, Internal Advisory Committee (formerly)

Chairman, Time Allocation Group for the Advanced Biomedical Computing Center (ABCC), formerly the Frederick Biomedical Supercomputing Center (FBSC)

NIH IT Board of Governors Advisory Committee to the Director (ACD), Subcommittee on Computational Biology

Member of the Normal P. Salzman Memorial Award in Virology with NIH

Pennsylvania Senatorial District Scholarship for period of undergraduate training (Awarded by competitive examination)

Pennsylvania Power and Light Scholarship for period of undergraduate training (Awarded by competitive examination)

U.S.P.H.S. Predoctoral Fellowship (1959)

U.S.P.H.S. Career Development Award 1965-1970

American Cancer Society Faculty Research Award 1970-1974

The U.S. Public Health Service Superior Award for "Development of powerful and imaginative computer graphic techniques that make possible an understanding of the structure, organization and evolution of genes." (This is the highest PHS award for civil-service employees.) April 23, 1982.

Research Interests:
 
 

Advanced computation on nucleic acid and protein sequences to define important functional regions, to detect relationships between them, and to predict higher order structure from primary sequences. The long-term goal is to derive the essential knowledge of the genome from the information encoded in gene sequences.

 

 
 
 
 
 
 
 
 
 
 
 
 
 

 BIBLIOGRAPHY

Journals:

 1.Maizel, J. V., Jr., Benson, A. A., and Tolbert, N. E.: Identification of phosphoryl choline as an important constituent of plant saps. Plant Physiol. 31: 407-408, 1956.

2.Maizel, J. V., Jr.: Evidence for multiple components in the structural protein of Type 1 poliovirus. Biochem. Biophys. Res. Commun. 13: 483-489, 1963.

3.Burkhardt, H. J., Maizel, J. V., Jr., and Mitchell, H. K.: Avenacin, an antimicrobial substance isolated from Avenua Sativa. II. Structure. Biochemistry 3: 426-431, 1964.

4.Maizel, J. V., Jr.: Preparative electrophoresis of proteins in acrylamide gels. Annals of the New York Academy, Symposium on Gel Electrophoresis 121(2): 382-390, 1964.

5.Maizel, J. V., Jr., Burkhardt, H. J., and Mitchell, H. K.: Avenacin, an antimicrobial substance isolated from Avena Sativa. I. Isolation and antimicrobial activity. Biochemistry 3: 424-426, 1964.

6.Scharff, M. D., Maizel, J. V., Jr., and Levintow, L.: Physical and immunological properties of a soluble precursor of the poliovirus capsid. Proc. Natl. Acad. Sci. USA 51: 329-337, 1964.

7.Summers, D. F., Maizel, J. V., Jr., and Darnell, J. E., Jr.: Evidence for virus-specific non-capsid proteins in poliovirus-infected HeLa cells. Proc. Natl. Acad. Sci. USA 54: 505-513, 1965.

8.Maizel, J. V., Jr.: Acrylamide gel electropherograms by mechanical fractionation. Radioactive adenovirus proteins. Science 151: 988-990, 1966.

9.Shapiro, A. L., Scharff, M. D., Maizel, J. V., Jr., and Uhr, J. W.: Polyribosomal synthesis and assembly of H and L chains of gamma globulin. Proc. Natl. Acad. Sci. USA 56: 216-221, 1966.

10.Shapiro, A .L., Scharff, M. D., Maizel, J. V., Jr., and Uhr, J. W.: Synthesis of excess light chains of gamma globulin by rabbit lymph node cells. Nature 211: 243-245, 1966.

11.Maizel, J. V., Jr., Phillips, B. A., and Summers, D. F.: Composition of artificially produced and naturally occurring empty capsides of poliovirus Type 1. Virology 32: 692-699, 1967.

 12.Shapiro, A. L., Vinuela, E., and Maizel, J. V., Jr.: Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. Biochem. Biophys. Res. Commun. 28: 815-820, 1967.

13.Summers, D. and Maizel, J. V., Jr.: Disaggregation of HeLa cell polysomes following infection with poliovirus. Virology 31: 550-552, 1967.

14.Summers, D., Maizel, J. V., Jr., and Darnell, J. E., Jr.: The decrease in size and synthetic activity of poliovirus polysomes late in one infectious cycle. Virology 31: 427-435, 1967.

15.Maizel, J. V., Jr. and Summers, D. F.: Evidence for differences in size and composition of the poliovirus-specific polypeptides. Virology 36: 48-54, 1968.

16.Maizel, J. V., Jr., White, D. O., and Scharff, M. D.: The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of Types 2, 7A and 12. Virology 36: 115-125, 1968.

17.Maizel, J. V., Jr., White, D. O., and Scharff, M. D.: The polypeptides of adenovirus. II. Soluble proteins, cores, top components and the structure of the virion. Virology 36: 126-136, 1968.

18.Phillips, B. A., Summers, D. F., and Maizel, J. V., Jr.: In vitro assembly of poliovirus-related particles. Virology 35: 216-226, 1968.

19.Summers, D. F. and Maizel, J. V., Jr.: Evidence for large precursor proteins in poliovirus synthesis. Proc. Natl. Acad. Sci. USA 59: 966-971, 1968.

20.Horwitz, M. S., Scharff, M. D., and Maizel, J. V., Jr.: Synthesis and assembly of adenovirus 2. I. Polypeptide synthesis, assembly of capsomeres morphogenesis of the virion. Virology 39: 682-694, 1969.

21.Shapiro, A. L. and Maizel, J. V., Jr.: Molecular weight estimation of polypeptides by SDS-polyacrylamide gel electrophoresis: Further data concerning resolving power and general considerations. Anal. Biochem. 29: 505-514, 1969.

22.Studier, F. W. and Maizel, J. V., Jr.: T7-directed protein synthesis. Virology 39: 575-586, 1969.

23.White, D. O., Scharff, M. D., and Maizel, J. V., Jr.: The polypeptides of adenovirus. III. Synthesis in infected cells. Virology 38: 395-406, 1969.

24.Cooper, P. D., Summers, D. F., and Maizel, J. V., Jr.: Evidence for ambiguity in the posttranslational cleavage of poliovirus proteins. Virology 41: 408-418, 1970.

25.Ehrenfeld, E., Maizel, J. V., Jr., and Summers, D. F.: Soluble RNA polymerase complex from poliovirus-infected HeLa cells. Virology 40: 840-846, 1970.

26.Horwitz, M., Maizel, J. V., Jr., and Scharff, M. D.: Molecular weight of adenovirus type 2 hexon polypeptide. J. Virol. 6: 569-571, 1970.

27.Maizel, J. V., Jr., Summers, D. F., and Scharff, M. D.: SDS-acrylamide gel electrophoresis and its application to the proteins of poliovirus and adenovirus-infected human cells. J. Cell. Physiol. 76: 273-288, 1970.

28.Rose, J. A., Maizel, J. V., Jr., Inman, J. K., and Shatkin, A. T.: The structural proteins of adenovirus-associated viruses. J. Virol. 8: 766-770, 1971.

29.Roumiantzeff, M., Maizel, J. V., Jr., and Summers, D. F.: Comparison of polysomal structures of uninfected and poliovirus infected HeLa cells. Virology 44: 239-248, 1971.

30.Roumiantzeff, M., Summers, D. F., and Maizel, J. V., Jr.: In vitro protein synthetic activity of membrane-bound poliovirus polyribosomes. Virology 44: 249-258, 1971.

31.Summers, D. F. and Maizel, J. V., Jr.: Determination of the gene sequence of poliovirus with pactamycin. Proc. Natl. Acad. Sci. USA 68: 2852-2856, 1971.

 32.Baum, S. G., Horwitz, M. S., and Maizel, J. V., Jr.: Studies of the mechanism of enhancement of human adenovirus infection in monkey cells by simian virus 40. J. Virol. 10: 211-219, 1972.

33.Leonard, K. R., Kleinschmidt, A. K., Agabian-Keshishian, N., Shapiro, L., and Maizel, J. V., Jr.: Structural studies on the capsid of Caulobacter crescentus bacteriophage O/Cbk. J. Mol. Biol. 71: 201-216, 1972.

34.Summers, D. F., Shaw, E. N., Stewart-Blair, M. L., and Maizel, J. V., Jr.: Inhibition of cleavage of large poliovirus specific precursor proteins in infected HeLa cells by inhibition of proteolytic enzymes. J. Virol. 10: 880-884, 1972 .

35.Contreras, G., Summers, D. F., Maizel, J. V., Jr., and Ehrenfeld, E.: HeLa cell nucleolar RNA synthesis after poliovirus infection. Virology 53: 120-129, 1973.

36.Pass, F. and Maizel, J. V., Jr.: Wart-associated antigens. II. Human immunity to viral structural proteins. J. Invest. Dermatol. 60: 307-311, 1973.

37.Shapiro, L. and Maizel, J. V., Jr.: Synthesis and structure of Caulobacter crescentus flagella. J. Bacteriol. 113: 478-485, 1973.

38.Stewart, M. L., Summers, D. F., Soeiro, R., Fields, B. N., and Maizel, J. V., Jr.: Purification of oncornaviruses by agglutination with concanavalin A. Proc. Natl. Acad. Sci. USA 70: 1308-1312, 1973.

39.Ishibashi, M. and Maizel, J. V., Jr.: The polypeptides of adenovirus V. Young virions, structural intermediates between top components and aged virions. Virology 57: 409-424, 1974.

40.Ishibashi, M. and Maizel, J. V., Jr.: The polypeptides of adenovirus VI. Early and late glycopeptides. Virology 58: 345-361, 1974.

41.Lundquist, R. E., Ehrenfeld, E., and Maizel, J. V., Jr.: Isolation of a viral polypeptide associated with poliovirus RNA polymerase. Proc. Natl. Acad. Sci. USA 71: 4773-4777, 1974.

42.Stewart, M. L. and Maizel, J. V., Jr.: Rapid analysis of oncornaviral RNA employing agglutination of virions with concanavalin A. Virology 59: 595-599, 1974.

43.Walter, G. and Maizel, J. V., Jr.: The polypeptides of adenovirus IV. Detection of early and late virus-induced polypeptides and their distribution in subcellular fractions. Virology 57: 402-408, 1974.

44.Stewart, M. L. and Maizel, J. V., Jr.: Friend leukemia and endogenous virus. I. Production of friend and endogenous C-type particles by mouse cells cultured in vitro. Virology 65: 55-66, 1975.
 
 

45.Stewart, M. L. and Maizel, J. V., Jr.: Friend leukemia and mouse endogenous viruses. II. Proteins of Friend leukemia and mouse endogenous C-type particles produced by BALB/c mouse cell cultures. Virology 65: 67-76, 1975.

46.Chin, W. and Maizel, J. V., Jr.: The polypeptides of adenovirus. VII. Further studies of early polypeptides in vivo and localization of E2 and E2A to the cell plasma membranes. Virology 71: 518-530, 1976.

47.Westphal, H., Meyer, J. M., and Maizel, J. V., Jr.: Mapping of adenovirus messenger RNA by electron microscopy. Proc. Natl. Acad. Sci. USA 73: 2069-2071, 1976.

48.Chin, W. and Maizel, J. V., Jr.: The polypeptides of adenovirus. VIII: The enrichment of E3 (11 K) in the nuclear matrix fraction. Virology 76: 79-89, 1977.

 49.Ishibashi, M., Chin, W. W., and Maizel, J. V., Jr.: The polypeptides of adenovirus. IX. Partial purification of early proteins and observations on late proteins of type 5 adenovirus. Virology 83: 1-15, 1977.

50.May, E., Maizel, J. V., Jr., and Salzman, N. P.: Mapping of transcription site of simian virus 40-specific late 16S and 19S mRNA by electron microscopy. Proc. Natl. Acad. Sci. USA 74: 496-500, 1977.

51.Meissner, H. C., Meyer, J., Maizel, J. V., Jr., and Westphal, H.: Visualization and mapping of late nuclear adenovirus RNA. Cell 10: 225-235, 1977.

52.Meyer, J., Neuwald, P. D., Lai, S. P., Maizel, J. V., Jr., and Westphal, H.: Electron microscopy of late adenovirus type 2 mRNA hybridized to double stranded viral DNA. J. Virol. 21: 1010-1018, 1977.

53.Neuwald, P. D., Meyer, J., Maizel, J. V., Jr., and Westphal, H.: Early gene expression and time course of viral DNA, mRNA, and protein synthesis. J. Virol. 21: 1019-1030, 1977.

54.Lundquist, R. E. and Maizel, J. V., Jr.: In vivo regulation of the poliovirus RNA polymerase. Virology 89: 484-493, 1978.

55.Lundquist, R. E. and Maizel, J. V., Jr.: Structural studies of the RNA component of the poliovirus replication complex. I. Purification and biochemical characterization. Virology 85: 434-444, 1978.

56.Meyer, J., Lundquist, R. E., and Maizel, J. V., Jr.: Structural studies of the RNA component of the poliovirus replication complex. II. Characterization by electron microscopy and autoradiography. Virology 85: 445-455, 1978.

57.Peterlin, B. M., Sullivan, M., Westphal, H., and Maizel, J. V., Jr.: Secondary structure map of psoralen-crosslinked adenovirus DNA studied by electron microscopy. Virology 86: 391-397, 1978.

58.Tilghman, S. M., Tiemeier, D. C., Seidman, J. G., Peterlin, B. M., Sullivan, M., Maizel, J. V., Jr., and Leder, P.: An intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene. Proc. Natl. Acad. Sci. USA 75: 725-729, 1978.

59.Konkel, D. A., Maizel, J. V., Jr., and Leder, P.: The evolution and sequence comparison or two recently diverged mouse chromosomal beta-globin genes. Cell 18: 865-873, 1979.

60.Lemkin, P., Shapiro, B., Lipkin, L., Maizel, J. V., Jr., Sklansky, J., and Schultz, M.: Preprocessing of electron micrographs of nucleic acid molecules for automatic analysis by computer. II. Noise removal and gap filling. Comput. Biomed. Res. 12: 615-630, 1979.

61.Lundquist, R. E., Sullivan, M., and Maizel, J. V., Jr.: Characterization of an isolate of poliovirus defective interfering particles. Cell 18: 759-769, 1979.

62.Shapiro, B., Lipkin, L., and Maizel, J. V., Jr.: Computerized generation of structure maps for nucleic acids. Comput. Biomed. Res. 12: 545-568, 1979.

63.Avvedimento, V. E., Vogeli, G., Yamada, Y., Maizel, J. V., Jr., Pastan, I., and de Crombrugghe, B.: correlation between splicing sites within an intron and their sequence complementarity with U1 RNA. Cell 21: 689-696, 1980.

64.Hieter, P. A., Max, E. E., Seidman, J. G., Maizel, J. V., Jr., and Leder, P.: Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments. Cell 22: 197-207, 1980.

65.Lenk, R., Storch, T., and Maizel, J. V., Jr.: Cell architecture during adenovirus infection. Virology 105: 19-34, 1980.

66.Oskarsson, M. K., McClements, W. L., Blair, D. G., Maizel, J. V., Jr., and VandeWoude, G. F.: Properties of a normal mouse cell DNA sequence (Sarc) homologous to the Src sequence of Moloney sarcoma virus. Science 207: 1222-1224, 1980.

67.Phillips, B. A., Lundquist, R. E., and Maizel, J. V., Jr.: Absence of subviral particles and assembly activity in HeLa cells infected with defective-interfering (DI) particles of poliovirus. Virology 100: 116-124, 1980.

68.Sherr, C. J., Fedeles, L. A., Oskarsson, M., Maizel, J. V., Jr., and VandeWoude, G. F.: Molecular cloning of Snyder-Theilen Feline leukemia and sarcoma viruses: comparative studies of feline sarcoma virus with its natural helper and with Moloney sarcoma. J. Virol. 241: 200-212, 1980.

69.Stewart, M. L., Crouch R. J., and Maizel, J. V., Jr.: A high resolution oligonucleotide map generated by restriction of polio-virus type 1 genomic RNA by ribonuclease III. Virology 104: 375-397, 1980.

70.Storch, T. G. and Maizel, J. V., Jr.: The early proteins of the nondefective Ad2-SV40 hybrid viruses: the 19K glycoprotein is coded by Ad2 early region 3. Virology 103: 54-67, 1980.

71.VandeWoude, G. F., Oskarsson, M. K., McClements, W. L., Enquist, L. W., Blair, D. G., Fischinger, P. J., Maizel, J. V., Jr., and Sullivan, M.: characterization of integrated Moloney sarcoma proviruses and flanking host sequences cloned in bacteriophage lambda. Cold Spring Harbor Symp., Quant. Biol. 44: 735-745, 1980.

72.Vogeli, G., Avvedimento, E. V., Sullivan, M., Maizel, J. V., Jr., Lozano, G., Adams, S. L., Pastan, I., and de Crombrugghe, B.: Isolation and characterization of genomic DNA coding for alpha-2 type I collagen. Nucleic Acids Res. 8: 1823-1837, 1980.

73.Lenk, R. P., Maizel, J. V., Jr., and Crouch, R. J.: Expression of two late adenovirus genes is altered by introducing antibodies against ribonucleoprotein into living Hela cells. Eur. J. Biochem. 121: 475-482, 1981.

74.Maizel, J. V., Jr. and Lenk, R. P.: Enhanced graphic matrix analysis of nucleic acid and protein sequences. Proc. Natl. Acad. Sci. USA 8: 7665-7669, 1981.

75.Max, E. E., Maizel, J. V., Jr., and Leder, P.: The nucleotide sequence of a 5.5 kb DNA segment containing the mouse kappa immunoglobulin J and C region genes. J. Biol. Chem. 256: 5116-5120, 1981.

76.McClain, K., Stewart, M., Sullivan, M., and Maizel, J. V., Jr.: Ribosomal binding sites on poliovirus RNA. Virology 113: 150-167, 1981.

77.Dhar, R., Ellis, R. W., Shih, T. Y., Oroszlan, S., Shapiro, B., Maizel, J. V., Jr., Lowy, D., and Scolnick, E.: The nucleotide sequence of the p21 transforming protein of Harvey murine sarcoma virus. Science 17: 934-937, 1982.

78.Hieter, P. A., Maizel, J. V., Jr., and Leder, P.: Evolution of human immunoglobulin kappa J region genes. J. Biol. Chem. 257: 1516-1522, 1982.

79.Inana, G., Shinohara, T., Maizel, J. V., Jr., and Piatigorsky, J.: Evolution and diversity of the crystallins: nucleotide sequence of a ß crysallin mRNA from the mouse lens. J. Biol. Chem. 257: 9064-9071, 1982.

80.Lipman, D. J. and Maizel, J. V., Jr.: Comparative analysis of nucleic acid sequences by their general constraints. Nucleic Acids Res. 10: 2723-2739, 1982.

 81.Shapiro, B. A., Lipkin, L. E., and Maizel, J. V., Jr.: An interactive technique for the display of nucleic acid structures. Nucleic Acids Res. 10: 7041-7052, 1982.

82.Chin, W. W., Maizel, J. V., Jr., and Habener, J. F.: Difference in sizes of human compared to murine alpha-subunits of the glycoprotein hormones arises by four-codon gene deletion or insertion. Endocrinology 112: 482-485, 1983.

83.Chatterjee, D. and Maizel, J. V., Jr.: Homology of adenoviral E3 glycoprotein with HLA-DR heavy chain. Proc. Natl. Acad. Sci. USA 81: 6039-6043, 1982.

84.Chen, M. J., Shimada, T., Moulton, A. D., Cline, A., Humphries, R. K., Maizel, J. V., Jr., and Nienhuis, A. W.: The functional human dihydrofolate reductase gene. J. Biol. Chem. 259(6): 3933-3943, 1984.

85.Nussinov, R., Shapiro, B., Lipkin, L. E,. and Maizel, J. V., Jr.: DNAase I hypersensitive sites may be correlated with genomic regions of large structural variation. J. Mol. Biol. 177: 591-608, 1984.

86.Nussinov, R., Shapiro, B., Lipkin, L. E., and Maizel, J. V., Jr.: Enhancer elements share local homologous twist angle variations with a helical periodicity.Biochim. Biophys. Acta 783: 246-257, 1984.

87.Sun, S. T., Tanaka, T., Nishio, I., Peetermans, J., Maizel, J. V., Jr., and Piatigorsky, J.: Direct observation of delta-crystallin accumulation by laser light-scattering spectroscopy in the chicken embryo lens. Proc. Natl. Acad. Sci. USA 81: 785-787, 1984.

88.Shapiro, B. A., Maizel, J. V., Jr., Lipkin, L. E., Currey, K., and Whitney, C.: Generating non-overlapping displays of nucleic acid secondary structure. Nucleic Acids Res. 12: 75-88, 1984.

89.Baroudy, B. M., Ticehurst, J. R., Miele, T. A., Maizel, J. V., Jr., Purcell, R. H., and Feinstone, S. M.: Sequence analysis of hepatitis A virus cDNA coding for capsid proteins and RNA polymerase. Proc. Natl. Acad Sci. USA 82: 2143-2147, 1985.

90.Bassel, D. R., Jayasuriya, A., Chatterjee, D., Sonenberg, N., Maizel, J. V., Jr., and Fields, B. N.: Sequence of reovirus hemagglutinin predicts a coiled-coil structure. Nature 315: 421-423, 1985.

91.Evans, D. M., Dunn, G., Minor, P. D., Schild, G. C., Cann, A. J., Stanway, G., Almond, J. W., Currey, K., and Maizel, J. V., Jr.: Increased neurovirulence associated with a single nucleotide change in a noncoding region of the Sabin type 3 poliovaccine genome. Nature 314: 548-550, 1985.

 92.Messer, M. I., Currey, K. M., O'Neill, B. J., Maizel, J. V., Jr., Levin, J. G., and Gerwin, B. I.: Functional analysis of reverse transcription by a frameshift pol mutant of murine leukemia virus. Virology 146: 146-152, 1985.

93.Chatterjee, D. and Maizel, J. V., Jr.: Sequence analysis of proteins. Gene Anal. Tech. 4: 27-40, 1986.

 94.Currey, K. M., Peterlin, B. M., and Maizel, J. V., Jr.: Secondary structure of poliovirus RNA: Correlation of computer-predicted with electron microscopically observed structure. Virology 148: 33-46, 1986.

95.Lockard, R. E., Currey, K. M., Browner, M., Lawrence, C., and Maizel, J. V., Jr.: Secondary structure model for mouse beta major globin mRNA derived from enzymatic digestion data, comparative sequence and computer analysis. Nucleic Acids Res. 14: 5827-5841, 1986.

96.McGeady, M. L., Wood, T. G., Maizel, J. V., Jr., and VandeWoude, G. F.: Sequences upstream from the mouse C-mos oncogene may function as a transcription termination signal. DNA 5(4): 289-298, 1986.

97.Nussinov, R., Owens, J., and Maizel, J. V., Jr.: Sequence signals in eukaryotic upstream regions. Biochim. Biophys. Acta 866: 109-119, 1986.

98.Shapiro, B., Nussinov, R., Lipkin, L. E., and Maizel, J.V., Jr.: A sequence analysis system encompassing rules for DNA helical distortion. Nucleic Acids Res. 14: 75-86, 1986.

99. Brandtrauf, P. W., Pincus, M. R., Carty, R. P., Maizel, J. V., Jr., Lubowsky, J., and Avitable, M.:  Correlation of structure with transforming activity of the P21-proteins with substitutions at position-12 and position-16.  J. Protein Chem. 6:  375-385, 1987.

100. Brandtrauf, P. W., Pincus, M. R., Maizel, J. V., Jr., Carty, R. P., Lubowsky, J., Avitable, M., Shirley, J. B., and Wagner, R. R.:  Structural effects of amino-acid substitutions on the matrix protein of vesicular stomatitis-virus.  J. Protein Chem. 6:  463-472, 1987.

 101.Konopka, A. K., Smythers, G. W., Owens, J., and Maizel, J. V., Jr.: Distance analysis helps to establish characteristic motifs in intron sequences. Gene Anal. Tech. 4: 63-74, 1987.

102.Le, S. Y., Currey, K. M., Nussinov, R., and Maizel, J. V., Jr.: Studies of frequently recurring substructures in human alpha-like globin mRNA precursors. Comput. Biomed. Res. 20: 563-582, 1987.

103.Nussinov, R., Barber, A., and Maizel, J. V., Jr.: The distribution of nucleotides near bacterial transcription initiation and termination sites show distinct signals that may affect DNA geometry. J. Mol. Evol. 26: 187-197, 1987.

104.Shapiro, B., Nussinov, R., Lipkin, L., and Maizel, J. V., Jr.: An interactive dot matrix system for locating significant features in nucleic acids molecules. J. Biomol. Struct. Dyn. 4: 697-706, 1987.

105.Le, S. Y., Chen, J. H., Currey, K. M., and Maizel, J. V., Jr.: A program for predicting significant RNA secondary structures. Comput. Appl. Biosci. 4: 153-159, 1988.

106.Le, S. Y., Chen, K. H., Braun, M. J., Gonda, M. A., and Maizel, J. V., Jr.: Stability of RNA stem loop structure and distribution of non-random structure in the human immunodeficiency virus (HIV-1). Nucleic Acids Res. 16: 5153-5168, 1988.

107.Le, S. Y., Chen, K. H., Nussinov, R., and Maizel, J. V., Jr.: An improved secondary structure computation method and its application to intervening sequences in the human alpha-like globin mRNA precursors.Comput. Appl. Biosci. 4(3): 337-344, 1988.

 108.Maizel, J. V., Jr.: Supercomputing in biomedical research: applications to sequence analysis and molecular biology. Proceedings of the Second International Symposium. Chicago, Cray Research, 1988, pp. 81-95.

 109.Maizel, J. V., Jr.: Supercomputing in molecular biology: applications to sequence analysis. IEEE Engineering in Medicine and Biology Magazine 7(4): 27-30, 1988.

110.Nakata, K., Kanehisa, M., and Maizel, J. V., Jr.: Discriminant analysis of promoter regions in E. Coli sequences. Comput. Appl. Biosci. 4(3): 367-371, 1988.

111.Owens, J., Chatterjee, D., Nussinov, R., Konopka, A. K., and Maizel, J. V., Jr.: A fixed-point alignment technique for detection of recurrent and common sequence motifs associated with biological features. Comput. Appl. Biosci. 4: 73-77, 1988.

112.Rivera, V. M., Welsh, J. D., and Maizel, J. V., Jr.: Comparative sequence analysis of the 5' noncoding region of the enteroviruses and rhinoviruses.Virology 165: 42-50, 1988.

113.Steven, A. C., Trus, B. L., Maizel, J. V., Jr., Unser, M., Parry, D. A. D., Wall, J. S., Hainfeld, J. F., and Studier, F. W.: Molecular substructure of a viral receptor-recognition protein - the GP17 tail-fiber of bacteriophage-T7. J. Mol. Biol. 200: 351-365, 1988.

114.Agrawal, S., Ikeuchi, T., Sun, D., Sarin, P. S., Konopka, A., Maizel, J. V., Jr., and Zamecnik, P. C.: Inhibition of human immunodeficiency virus in early-infected and chronically-infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues.Proc. Natl. Acad. Sci. USA 86: 7790-7794, 1989.

 115.Brandtrauf, P. W., Pincus, M. R., Carty, R. P., Lubowsky, J., Avitable, M., Kung, H. F., and Maizel, J. V., Jr.: Conformational effects of amino-acid substitutions at positions 10, 12, and 13 in the P21 protein. J. Protein Chem. 8: 79-86, 1989.

 116.Fenrick, R., Malim, M. H., Hauber, J., Le, S. Y., Maizel, J. V., Jr., and Cullen, B. R.: Functional analysis of the tat trans-activator of the human immunodeficiency virus type 2. J. Virol. 63: 5006-5012, 1989.

 117.Hanly, S. M., Rimsky, L. T., Malim, M. H., Kim, J. H., Hauber, J., Dudon, M. D., Le, S. Y., Maizel, J. V., Jr., Cullen, B. R., and Greene, W.C.: Comparative analysis of the HTLV-1 Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements. Genes Dev. 3: 1534-1544, 1989.

 118.Le, S. Y., Chen, J. H., Chatterjee, D., and Maizel, J. V., Jr.: Sequence divergence and open regions of RNA secondary structures in the envelope regions of the seventeen human immunodeficiency virus isolates. Nucleic Acids Res. 17: 3275-3288, 1989.

119.Le, S. Y., Chen, J. H., and Maizel, J. V., Jr.: Thermodynamic stability and statistical significance of potential stem loop structures situated at the frameshift sites of retroviruses.Nucleic Acids Res. 17: 6143-6152, 1989.

 120.Le, S. Y. and Maizel, J. V., Jr.: A method for assessing the statistical significance of RNA folding. J. Theor. Biol. 138: 495-510, 1989.

 121.Le, S. Y., Nussinov, R., and Maizel, J. V., Jr.: Tree graphs of RNA secondary structures and their comparisons. Comput. Biomed. Res. 22: 461-473, 1989.

 122.Le, S. Y., Owens, J., Nussinov, R., Chen, J. H., Shapiro, B., and Maizel, J. V., Jr.: RNA secondary structures: Comparison and determination of frequently recurring substructures by consensus. Comput. Appl. Biosci. 5: 205-210, 1989.

123.Malim, M. H., Bohnlein, S., Fenrick, R., Le, S. Y., Maizel, J. V., Jr., and Cullen, B. R.: Functional comparison of the Rev trans-activators encoded by different primate immunodeficiency virus species. Proc. Natl. Acad. Sci. USA 89: 8222-8226, 1989.

 124.Malim, M. H., Hauber, J., Le, S. Y., Maizel, J. V., Jr., and Cullen, B. R.: The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. Nature 338: 254-257, 1989.

 125.Margalit, H., Shapiro, B. A., Oppenheim, A. B., and Maizel, J. V., Jr.: Detection of common motifs in RNA secondary structures. Nucleic Acids Res. 17: 4829-4845, 1989.

 126.Nakata, K. and Maizel, J. V., Jr.: Prediction of operator-binding protein by discriminant analysis. Gene Anal. Tech. 6: 111-119, 1989.

 127.Barber, A. M., Hizi, A., Maizel, J. V., Jr., Hughes, S. H.: HIV-1 reverse transcriptase: structure predictions for the ploymerase domain. Aids Res. Human Retroviruses 6: 1061 1072, 1990.

 128.Barber, A. M. and Maizel, J. V., Jr.: SequenceEditingAligner: A multiple sequence editor and aligner. Gene Anal. Tech. 7: 39-45, 1990.

 129.Chen, J. H., Le, S. Y., Shapiro, B., Currey, K. M., and Maizel, J. V., Jr.: A computational procedure for assessing the significance of RNA secondary structure. Comput. Appl. Biosci. 6: 7-18, 1990.

 130.Le, S. Y., Chen, J. H., and Maizel, J. V., Jr.: Efficient searches for unusual folding regions in RNA sequences. In Sarma, R. H. and Sarma, M. H. (Eds.): Proceedings of the 6th Conversations in Biomolecular Stereodynamics. New York, Adenine Press, 1990, (1) pp. 127-136.

 131.Le, S. Y., Malim, M. H., Cullen, B. R., and Maizel, J. V., Jr.: A highly conserved RNA folding region adjacent to the cleavage site of OMP/TMP in the envelope gene of primate immunodeficiency viruses. Nucleic Acids Res. 18: 1613-1623, 1990.

 132.Le, S. Y., Nussinov, R., and Maizel, J. V., Jr.: Studies of local stability in histone, U-SnRNA and globin precursor mRNAs around transcription termination sites. Comput. Math. Appl. 20: 49-56, 1990.

 133.Nussinov, R., Shapiro, B., Le, S. Y., and Maizel, J. V., Jr.: Speeding up the dynamic algorithm for planar RNA folding. Math. Bios. 100: 33-47, 1990.

 134.Peitsch, M. C., Amiguet, P., Guy, R., Brunner, J., Maizel, J. V., Jr., and Tschopp, J.: Localization and molecular modelling of the membrane-inserted domain of the ninth component of human complement and perforin. Mol. Immunol. 27: 589-602, 1990.

 135.Tiley, L. S., Brown, P. H., Le, S. Y, Maizel, J. V., Clements, J. E., and Cullen, B. R.: Visna virus encodes a posttrancriptional regulator of viral structural gene-expression.Proc. Natl. Acad. Sci. USA 87: 7497-7501, 1990.

 136. Le, S. Y., Chen, J. H, and Maizel, J. V., Jr.: Detection of unusual RNA folding regions in HIV and SIV sequences. Comput. Appl. Biosci. 7: 51-55, 1991.

 137.Le, S. Y., Shapiro, B. A., Chen, H., Nussinov, R., and Maizel, J. V., Jr.: RNA pseudoknots downstream of the frameshift sites of retroviruses. Genet. Anal. Tech. Appl. 8(7): 191-205, 1991.

 138.Chen, J. H., Le, S. Y., and Maizel, J. V., Jr.: A Procedure for RNA pseudoknot prediction. Comput. Appl. Biosci. 8: 243-248, 1992.

 139.Dayton, E. T., Konings, D. A. M., Powell, D. M., Shapiro, B. A., Butini, L., Maizel, J. V., Jr., and Dayton, A. I.: Extensive sequence specific information throughout the CAR/RRE, the target sequence of the HIV-1 rev protein. J. Virol. 66: 1139-1151, 1992.

 140.Jaroszewski, J. W., Syi, J. L., Maizel, J. V., Jr., and Cohen, J. S.: Towards rational design of antisense DNA: molecular modelling of phosphorothioate DNA analogues.Anticancer Drug Des. 7: 253-262, 1992.

 141.Konings, D. A. M., Nash, M., Maizel, J. V., Jr., and Arlinghaus, R. B.: Novel GACG hairpin pair motif in the 5' untranslated region of type-C retroviruses related to murine leukemia-virus. J. Virol. 66: 632-640, 1992.

 142.Le, S. Y., Chen, J. H., Sonenberg, N., and Maizel, J.V., Jr.: Conserved tertiary structure elements in the 5' untranslated region of human enteroviruses and rhinoviruses. Virology 191: 858-866, 1992.

 143.Le, S. Y., Chen, J. H., and Maizel, J.V., Jr.: Identification of unusual RNA folding patterns encoded by bacteriophage-T4 gene 60. Gene 24: 21-28, 1993.

 144.Le, S. Y., Chen, J. H., and Maizel, J.V., Jr.: Prediction of alternative RNA secondary structures based on fluctuating thermodynamic parameters. Nucleic Acids Res. 21: 2173 2178, 1993.

145.Le, S. Y., Chen, J. H., Sonenberg, N., and Maizel, J. V., Jr.: Conserved tertiary structural elements in the 5' nontranslated region of cardiovirus, aphthovirus and hepatitis A virus RNAs. Nucleic Acids Res. 21(10): 2445-2451, 1993.

 146.Le, S. Y., Sonenberg, N., and Maizel, J. V., Jr.: Distinct structural elements and internal entry of ribosomes in mRNA3 encoded by infectious bronchitis virus. Virology 198: 405 411, 1994.

 147.Le, S. Y., Pattabiraman, N., and Maizel, J. V.: RNA tertiary structure of the HIV RRE domain II containing non-Watson-Crick base pairs GG and GA: molecular modeling studies. Nucleic Acids Res. 22(19): 3966-3976, 1994.

 148.Le, S. Y., Sonenberg, N., and Maizel, J. V.: Unusual folding regions and ribosome landing pad within hepatitis C virus and pestivirus RNAs. Gene 154: 137-143, 1995.

 149.Shapiro, B. A., Chen, J. H., Busse, T., Navetta, J., Kasprzak, W., and Maizel, J. V., Jr.: Optimization and performance analysis of a massively parallel dynamic programming algorithm for RNA secondary structure prediction. The International Journal of Supercomputer Applications 9(1): 29-39, 1995.

 150.Le, S. Y., Zhang, K., and Maizel, J. V., Jr.: A method for predicting common structures of homologous RNAs. Comput. Biomed. Res. 28: 53-66, 1995.

 151.Bisant, D. and Maizel, J. V., Jr.: Identification of ribosome binding sites in Escherichia coli using neural network models. Nucleic Acids Res. 23(9): 1632-1639, 1995.

 152.Le, S. Y., Siddiqui, A., and Maizel, J. V., Jr.: A common structural core in the internal ribosome entry sites of picornavirus, hepatitis C virus, and pestivirus. Virus Genes 12(2): 135-147, 1996.

 153.Le, S. Y. and Maizel, J. V., Jr.: A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs. Nucleic Acids Res. 25(2): 362-369, 1997.

 154.Geller, M., Miller, M., Swanson, S. M., Maizel, J.: Analysis of the structure of HIV-1 protease complexed with a hexapeptide inhibitor. Part II: molecular dynamic studies of the active site region. Protein Struct. Funct. Genet. 27: 195-203, 1997.

 155.Chen, Jih-H., Le, S-Y., Shapiro, B. A., and Maizel, J. V.: Optimization of an RNA folding algorithm for parallel architectures. Parallel Computing 24: 1617-1634, 1998.

 156.Le, S-Y., Liu, W-M., and Maizel, J. V., Jr.: Phylogenetic evidence for the improved RNA higher-order structure in internal ribosome entry sequences of HCV and pestiviruses. Virus Genes 17(3): 279-295, 1998.

157.Le, S-Y., Chen, J-H., Pattabiraman, N., and Maizel, J. V., Jr.: Ion-RNA interactions in the RNA pseudoknot of a ribosomal frameshifting site: Molecular modeling studies. J. Biomol. Struct. Dyn. 16(1): 1-11, 1998.

158.Le, S. Y. and Maizel, J. V., Jr.: Evolution of a common structural core in the internal ribosome entry sites of picornavirus.Virus Genes 16(1): 25-38, 1998.

 159.Pramodh, V., Pattabiraman, N., Le, S-Y., and Maizel, J. V., Jr.: A molecular modeling study of antibiotics-RNA interactions: Application to HIV-1 Rev response element. J. Mol. Struct. (Theo. Chem.) 423: 125-136, 1998.

 160.Vishveshwara, S., Jacob, R., Nadig, G., and Maizel, Jr., J. V.: The role of lysine-41 in RNase A catalysis A quantum chemical study on the active site-ligand complex. J. Mol. Struct. 471: 1-11, 1998.

 161.Tsai, C-J., Maizel, J. V., Jr., and Nussinov, R.: Distinguishing between sequential and non-sequentially folded proteins: Implications for folding and misfolding. Protein Science 8: 1591-1604, 1999.

 162.Chen, J-H., Le, S-Y., and Maizel, J. V.: Prediction of common secondary structures of RNAs: A genetic algorithm approach.Nucleic Acids Res. 28(4): 991-999, 2000.

 163.Chen, S-L., Le, S-Y., Newton, D. L., Maizel, J. V., Jr., and Rybak, S. M.: A gender specific mRNA encoding a cytotocix ribonuclease contains a 3'UTR of unusual length and structure. Nucleic Acis Res. 28(12): 2375-2382, 2000.

Books and Book Chapters:

 1.Darnell, J. E., Girard, M., Baltimore, D., Summers, D. F., and Maizel, J. V.: The synthesis and translation of poliovirus RNA. The Molecular Biology of Viruses. New York, Academic Press, 1967, pp. 375-401.

2.Maizel, J. V., Jr.: Acrylamide gel electrophoresis and proteins and nucleic acids. In Habel, K. and Salzman, N. P. (Eds): Fundamental Techniques in Virology. Chapter 32. New York, Academic Press, 1969, pp. 334-362.

3.Summers, D. F., Roumiantzeff, M., and Maizel, J. V., Jr.: The translation and processing of poliovirus proteins. In Wolstenholme, G. E. W. and O'Connor, M. (Eds.): CIBA Foundation Symposium on Strategy of the Viral Genome. New York, Churchill Livingston, London, Gloucester Place, 1971, pp. 111-133.

4.Maizel, J. V., Jr.: Polyacrylamide gel electrophoresis of viral proteins. In Maramorosch, K. and Koprowski, H. (Eds): Methods in Virology. Volume 5. New York, Academic Press, 1971, pp. 179-246.

5.McCl Genetics, ICN-UCLA Symposium on Molecular and Cellular Biology. Vol. VIII, New York, Academic Press, 1980, pp. 95-104.

Journals in Press:

 1.Tsai, C-J., Maizel, J. V., and Nussinov, R.: Anatomy of protein structures: Visualizing how a 1-D protein chain folds into a 3-D shape. Proc. Natl. Acad. Sci. USA, 2000.

Books and Book Chapters in Press:

 1.Tsai, C-J., Norel, R., Wolfson, H., Maizel, J. V., and Nussinov, R.: Protein-ligand interactions: Energetic contributions and shape complementarity. In Robertson, S. (Ed.): Encyclopedia of Life Sciences. London, Macmillan Reference Limited, 2000.

Manuscripts Submitted:

 1.Le, S-Y., Liu, W-M., Chen, J-H., and Maizel, J. V., Jr.: Noncentral student's t distribution of the local thermodynamic stability in the complete genome sequence. J. Theor. Biol., 2000.

Manuscripts in Preparation:

 Symposiums:

 1.Oskarsson, M. K., McClements, W. L., Blair, D. G., Maizel, J. V., Jr., and VandeWoude, G. F.: Properties of a normal mouse cell DNA sequence (Sarc) homologous to the Src sequence of Moloney sarcoma virus. ICN-UCLA Symposium, 1980.

2.Parnes, J. R., Maizel, J. V., Jr., and Seidman, J. G.: The Beta-2 microglobulin gene: Evolutionary relationships. In Janeway, C., Sercarz, E. E., Wigsell, H., and Fox, C.F. (Eds.): ICN-UCLA Symposium on Molecular and Cellular Biology, Immunoglobulin Idiotypes and Their Expression. Vol. XX, New York, Academic Press, 1981, pp. 327-336.

3.Shapiro, B. A., Maizel, J. V., Jr., and Lipkin, L. E.: Computer analysis and synthesis of nucleic acid secondary structure. Proceedings IXth Annual World Association for Medical Informatics Meeting, April 27, 1981, pp. 93-98.

4.Hausheer, F. H., Colvin, O. M., Barnett, G., Baylin, S., Crum, C. L., and Maizel, J. V., Jr.: Multidisciplinary analysis and design of anticancer drugs in the supercomputer environment. Third International Symposium - Science and Engineering on Cray Supercomputers, September 1987, pp. 344-347.

 5.Maizel, J. V., Jr.: Supercomputing in biomedical research. Proceedings of the Second International Conference on Supercomputing: Industrial Supercomputer Applications and Computations. St. Petersburg, FL, Internt'l. Supercomputing Inst., 1987, pp. 344-347.

6.Hausheer, F., Barnett, G., Colvin, M., and Maizel, J. V., Jr.: Analysis and prospective design of drugs for the treatment of cancer and AIDS by supercomputer. Presentation at ICS 1988 Third International Conference on Supercomputing and Second World Supercomputer Exhibition. May 1988, pp. 201-206.