Meaning of PDD term "Protein - Disease Correlation"

Protein - Disease Correlation

• A Protein - Disease Correlation is the relationship of a protein with a disease condition reported in one or more literature references.

• Each protein - disease correlation is assigned a unique PDC ID number in the PDD database.

• There must be a significant fold-change of protein concentration reported in the literature cited for the correlation to be interesting and entered into the PDD.

• Different fold-changes for the same protein-disease correlation may be reported from several literature references or different sample sources.

• A set of protein changes may be associated with a disease and consitute a protein pattern.

• Protein fold-change patterns may be compared for different diseases.

• Various metrics and plots can be computed for illustrating differences between protein patterns for different disease states.